Reference: Both UFH and NAH alleviate shedding of endothelial glycocalyx and coagulopathy in LPS-induced sepsis
Sepsis commonly progresses to disseminated intravascular coagulation and induces the activation of heparanase (HPA) and the shedding of endothelial glycocalyx constituents, including syndecan-1 (SDC-1) and heparan sulphate (HS). However, the degradation of glycocalyx and its association with coagulation disorders remains undetermined.
Tags: Glycocalyx, Heparanase, Septic
Reference: Ascorbate protects endothelial barrier function during septic insult: Role of protein phosphatase type 2A
Abstract Endothelial barrier dysfunction contributes to morbidity in sepsis. We tested the hypothesis that raising the intracellular ascorbate concentration protects the endothelial barrier from septic insult by inhibiting protein phosphatase type 2A.
Categories: I-RECOVER Post-Vaccine
Tags: Endothelial Barrier, Septic