Authors: Izquierdo JL, Soriano JB, Gonzalez Y, Lumbreras S PMID: 35084258 PMCID: PMC8795755 DOI: 10.1177/00368504221074574 Abstract Infection by SARS-CoV-2 causing coronavirus disease 2019 (COVID-19) can be associated with serious and life-threatening conditions, including acute respiratory distress syndrome (ARDS). Severity and mortality have been related to a cytokine storm, an imbalance of oxidative stress, and a [...]

Authors: Assimakopoulos SF, Aretha D, Kominos D, Dimitropoulou D, Lagadinou M PMID: 34182881 DOI: 10.1080/23744235.2021.1945675 Abstract Background: N-acetyl-cysteine (NAC) has been previously shown to exert beneficial effects in diverse respiratory diseases, through antioxidant and anti-inflammatory actions. Our aim was to evaluate NAC potential impact in hospitalised patients with COVID-19 pneumonia, in [...]

Authors: Shi Z, Puyo CA PMID: 33177829 PMCID: PMC7649937 DOI: 10.2147/TCRM.S273700 Abstract The novel coronavirus disease (COVID-19) is caused by a virus (SARS-Cov-2) and is known for inducing multisystem organ dysfunction associated with significant morbidity and mortality. Current therapeutic strategies for COVID-19 have failed to effectively reduce mortality rate, especially for elderly patients. A newly [...]

Authors: De Flora S, Balansky R, La Maestra S PMID: 32780893 PMCID: PMC7436914 DOI: 10.1096/fj.202001807 Abstract COVID-19 may cause pneumonia, acute respiratory distress syndrome, cardiovascular alterations, and multiple organ failure, which have been ascribed to a cytokine storm, a systemic inflammatory response, and an attack by the immune system. Moreover, an oxidative stress imbalance has [...]

Authors: Huang X, Han S, Liu x, Wang T, Xu H PMID: 32010252 PMCID: PMC6966138 DOI: 10.3892/etm.2019.8285 Abstract Sepsis commonly progresses to disseminated intravascular coagulation and induces the activation of heparanase (HPA) and the shedding of endothelial glycocalyx constituents, including syndecan-1 (SDC-1) and heparan sulphate (HS). However, the degradation of glycocalyx and its association with [...]

Schmitt B, Vicenzi M, Garrel C, Denis FM. PMID: 26262996 PMCID: PMC4536296 DOI: 10.1016/j.redox.2015.07.012 Abstract Glutathione (GSH) is critical to fight against oxidative stress. Its very low bioavailability limits the interest of a supplementation. The purpose of this study was to compare the bioavailability, the effect on oxidative stress markers and the safety of [...]