Auhtors: Patra KC, Hay N PMID: 24196563 PMCID: PMC3875752 DOI: 10.18632/oncotarget.1563 Abstract It is well established that cancer cells differ from most somatic adult cells by their high rate of aerobic glycolysis despite oxidative phosphorylation. This distinct property of cancer cells is often used for tumor imaging in vivo following the administration of the labeled [...]

Auhtors: Mathupala SP, Ko YH, Pedersen PL PMID: 19101634 PMCID: PMC2714668 DOI: 10.1016/j.semcancer.2008.11.006 Abstract The most common metabolic hallmark of malignant tumors, i.e., the "Warburg effect" is their propensity to metabolize glucose to lactic acid at a high rate even in the presence of oxygen. The pivotal player in this frequent cancer phenotype is mitochondrial-bound [...]

Auhtors: Halma MT, Tuszynski J, Marik P PMID: 198801 PMCID: PMC431708 DOI: 10.1073/pnas.74.9.3735 Abstract A tumorigenic anchorage-dependent cell line (H-91) was established in culture from an azo-dye-induced rat ascites hepatoma. When grown in a glucose-containing medium the cells exhibit high rates of lactic acid production characteristic of rapidly growing tumor cells. However, when glucose is [...]