Authors: Li G, Wu Z, Shang J, Xie Z, Chen C, Zhang C PMID: 33524789 DOI: 10.1016/j.biopha.2021.111286 Abstract Metformin is the first-line option for treating newly diagnosed diabetic patients and also involved in other pharmacological actions, including antitumor effect, anti-aging effect, polycystic ovarian syndrome prevention, cardiovascular action, and neuroprotective effect, etc. However, the mechanisms of [...]

Authors: Bharath LP, Agrawal M, McCambridge G, Nichols DA, Hasturk H, Liu J et al. PMID: 32402267 PMCID: PMC7217133 DOI: 10.1016/j.cmet.2020.04.015 Abstract Age is a non-modifiable risk factor for the inflammation that underlies age-associated diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine profiling and bioinformatic analyses showed that Th17 cytokine production differentiates [...]

Auhtors: De Santi M, Baldelli G, Diotallevi A, Galluzzi L, Schiavano GF, Brandi G PMID: 30635619 PMCID: PMC6329809 DOI: 10.1038/s41598-018-37247-6 Abstract Autophagy is a cellular mechanism by which cells degrade intracellular components in lysosomes, maintaining cellular homeostasis. It has been hypothesized that autophagy could have a role in cancer prevention through the elimination of damaged [...]