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Authors: Kakavas S, Karayiannis D, Mastora Z PMID: 34684460 PMCID: PMC8537261 DOI: 10.3390/nu13103458 Abstract There is an ongoing need for new therapeutic modalities against SARS-CoV-2 infection. Mast cell histamine has been implicated in the pathophysiology of COVID-19 as a regulator of proinflammatory, fibrotic, and thrombogenic processes. Consequently, mast cell histamine and its receptors represent promising [...]
Categories: I-RECOVER Post-Vaccine
Tags: COVID-19, Histamine, Immunonutrition, Mast Cells
SARS-CoV-2 infection is required for COVID-19, but many signs and symptoms of COVID-19 differ from common acute viral diseases. SARS-CoV-2 infection is necessary but not sufficient for development of clinical COVID-19 disease. Currently, there are no approved pre- or post-exposure prophylactic COVID-19 medical countermeasures. Clinical data suggest that famotidine may mitigate COVID-19 disease, but both mechanism of action and rationale for dose selection remain obscure.
Categories: MATH+
Authors: Malone RW, Tisdall P, Fremont-Smith P, Liu Y, Huang XP, White KM PMID: 32702719 PMCID: PMC7336703 doi: 10.21203/rs.3.rs-30934/v3 Abstract SARS-CoV-2 infection is required for COVID-19, but many signs and symptoms of COVID-19 differ from common acute viral diseases. Currently, there are no pre- or post-exposure prophylactic COVID-19 medical countermeasures. Clinical data suggest that famotidine [...]
Categories: I-CARE Early Covid
Tags: COVID-19, Famotidine, Histamine, Mast Cells
Authors: Bawazeer MA, Theoharides TC PMID: 31669588 DOI: 10.1016/j.ejphar.2019.172760 Abstract Mast Cells (MCs) are critical for allergic reactions but also play important roles in inflammation, following stimulation by non-allergic triggers such as cytokines. Upon stimulation, MCs secrete numerous newly synthesized mediators, but the mechanism of the release of chemokines, which are important in the pathogenesis [...]
Categories: I-RECOVER Long Covid
Tags: Mast Cells
Authors: Patel AB, Theoharides TC PMID: 28404689 DOI: 10.1124/jpet.117.240564 Abstract Mast cells (MCs) are critical for allergic reactions but are also important in inflammatory processes. Stimulation by neuropeptides, such as substance P (SP) and neurotensin (NT), leads to release of preformed molecules stored in numerous MC secretory granules and newly synthesized proinflammatory mediators, including tumor [...]
Categories: I-RECOVER Long Covid, I-RECOVER Post-Vaccine
Tags: Mast Cells, Methoxyluteolin
Authors: Weng Z, Patel AB, Panagiotidou S, Theoharides TC PMID: 25498791 PMCID: PMC4388775 DOI: 10.1016/j.jaci.2014.10.032 Abstract Background: Mast cells (MCs) are hematopoietic cells that mature in tissues and are involved in allergy, immunity, and inflammation by secreting multiple mediators. The natural flavone luteolin has anti-inflammatory actions and inhibits human mast cells (MCs). Objective: We sought [...]
Categories: I-RECOVER Long Covid, I-RECOVER Post-Vaccine
Tags: Mast Cells, Tetramethoxyluteolin
Authors: Weng Z, Zhang B, Asadi S, Sismanopoulos N, Butcher A. PMID: 22470478 PMCID: PMC3314669 DOI: 10.1371/journal.pone.0033805 Abstract Mast cells are immune cells critical in the pathogenesis of allergic, but also inflammatory and autoimmune diseases through release of many pro-inflammatory cytokines such as IL-8 and TNF. Contact dermatitis and photosensitivity are skin conditions that involve [...]
Categories: I-CARE Early Covid, I-CARE Flu and RSV, I-PREVENT, I-RECOVER Post-Vaccine
Tags: Cromolyn, Mast Cells, quercetin
Authors: Klooker TK, Braak B, Koopman KE, Welting O, Wouters MM, Schemann M PMID: 20650926 DOI: 10.1136/gut.2010.213108 Abstract Background: Mast cell activation is thought to be involved in visceral hypersensitivity, one of the main characteristics of the irritable bowel syndrome (IBS). A study was therefore undertaken to investigate the effect of the mast cell stabiliser [...]
Categories: I-RECOVER Post-Vaccine
Tags: Ketotifen, Mast Cells