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Authors: Puskarich MA, Ingraham NE, Merck LH, Driver BE, Wacker DA, Black LP PMID: 35294537 PMCID: PMC8928006 DOI: 10.1001/jamanetworkopen.2022.2735 Abstract Importance: SARS-CoV-2 viral entry may disrupt angiotensin II (AII) homeostasis, contributing to COVID-19 induced lung injury. AII type 1 receptor blockade mitigates lung injury in preclinical models, although data in humans with COVID-19 remain mixed. [...]
Categories: I-CARE Early Covid
Authors: Nejat R, Sadr AS, Freitas BT, Murray J, Pegan SD PMID: 34319871 DOI: 10.18433/jpps31931 Abstract Purpose: SARS-CoV-2 infection is associated with substantial mortality and high morbidity. This study tested the effect of angiotensin II type I receptor blocker, losartan, on SARS-CoV-2 replication and inhibition of the papain-like protease of the virus. Methods: The dose-dependent [...]
Categories: MATH+
Tags: losartan, SARS-CoV-2