Authors: Cruz AF, Ruiz-Antoran B, Gomez AM, Lopez AS doi: https://doi.org/10.1101/2020.05.22.20110544 Abstract Objective We aim to determine the impact of steroid use in COVID-19 pneumonia in-hospital mortality. Design We performed a single-centre retrospective cohort study. Setting A University hospital in Madrid, Spain, during March 2020. Participants Patients admitted with SARS-CoV-2 pneumonia. Exposures Patients treated with [...]

Authors: Iglesias J, Vassallo AV, Patel V, Sullivan JB, Cavanaugh J, Elbaga Y PMID: 32194058 DOI: 10.1016/j.chest.2020.02.049 Abstract Background: Sepsis is a major public health burden resulting in 25% to 30% in-hospital mortality and accounting for over 20 billion dollars of US hospital costs. Research question: Does hydrocortisone, ascorbic acid, thiamine (HAT) therapy improve clinical [...]

Authors: Meduri GU, Bridges L, Shih MC, Marik PE, Siemienluk RA, Kocak M PMID: 26508525 Abstract PURPOSE: To investigate the effect of prolonged glucocorticoid treatment for patients with acute respiratory distress syndrome (ARDS). METHODS: We conducted two sets of intention-to-treat analyses: (1) a primary analysis of individual patients' data (IPD) of four randomized controlled trials [...]

Authors: Thomas BJ, Porritt RA, Hertzog PJ, Bardin PG PMID: 25417801 PMCID: PMC5384105 DOI: 10.1038/srep07176 Abstract Glucocorticosteroids (GCS) are used on a daily basis to reduce airway inflammation in asthma and chronic obstructive pulmonary disease (COPD). This treatment is usually escalated during acute disease exacerbations, events often associated with virus infections. We examined the impact [...]

Authors: Leuner B, Caponiti JM, Gould E PMID: 21692136 PMCID: PMC4756590 DOI: 10.1002/hipo.20947 Abstract Oxytocin has been linked to social behavior, including social recognition, pair bonding and parenting, but its potential role in promoting neuronal growth has not been investigated. We show here that oxytocin, but not vasopressin, stimulates both cell proliferation and adult neurogenesis [...]

Authors: Duma D, Collins JB, Chou JW, Cidlowski JA PMID: 20940427 PMCID: PMC4772900 DOI: 10.1126/scisignal.2001077 Abstract Males and females show differences in the prevalence of many major diseases that have important inflammatory components to their etiology. These gender-specific diseases, which include autoimmune diseases, hepatocellular carcinoma, diabetes, and osteoporosis, are largely considered to reflect the actions [...]

Authors: Elenkov IJ PMID: 15265778 DOI: 10.1196/annals.1321.010 Abstract Evidence accumulated over the last 5-10 years indicates that glucocorticoids (GCs) inhibit the production of interleukin (IL)-12, interferon (IFN)-gamma, IFN-alpha, and tumor necrosis factor (TNF)-alpha by antigen-presenting cells (APCs) and T helper (Th)1 cells, but upregulate the production of IL-4, IL-10, and IL-13 by Th2 cells. Through [...]