Auhtors: Fung J Abstract Our understanding of cancer is slowly undergoing a revolution, allowing for the development of more effective treatments. For the first time ever, the death rate from cancer is showing a steady decline . . . but the “War on Cancer” has hardly been won. In The Cancer Code, Dr. Jason Fung [...]

Auhtors: Seyfried TN, Arismendi-Morillo G, Mukherjee P, Chinopoulos C PMID: 33251492 PMCID: PMC7677709 DOI: 10.1016/j.isci.2020.101761 Abstract ATP is required for mammalian cells to remain viable and to perform genetically programmed functions. Maintenance of the ΔG'ATP hydrolysis of -56 kJ/mole is the endpoint of both genetic and metabolic processes required for life. Various anomalies in mitochondrial [...]

Auhtors: Hope JR Abstract How does a trained physician beat terminal cancer when he, himself, gets it? · The answer will both shock and surprise you, as it is often NOT the same treatment that physicians prescribe for their patients. · Dr.Hope takes you through successful survival stories of doctor after doctor -and he explains [...]

Auhtors: Diorio C, Kelly KM, Afungchwi GM, Ladas EJ, Marjerrison S PMID: 32614139 DOI: 10.1002/pbc.28324 Abstract Traditional and complementary medicine (T&CM) strategies are commonly used by pediatric cancer patients. Nutritional approaches to T&CM include bioactive compounds, supplements, and herbs as well as dietary approaches. Pediatric cancer patients and their families commonly request and use nutritional [...]

Authors: Zeh HJ, Bahary N, Boone BA, Singh AD, Normolle Dp, Hogg ME PMID: 32156749 PMCID: PMC8086597 DOI: 10.1158/1078-0432.CCR-19-4042 Abstract Purpose: We hypothesized that autophagy inhibition would increase response to chemotherapy in the preoperative setting for patients with pancreatic adenocarcinoma. We performed a randomized controlled trial to assess the autophagy inhibitor hydroxychloroquine in combination with [...]

Auhtors: Han MA, Storman D, Al-Rammahy H, Tang S, Hao Q, Leung G, et al. PMID: 32226046 PMCID: PMC7105118 DOI: 10.1371/journal.pone.0230721 Abstract Background: A number of studies have reported on associations between reproductive factors, such as delivery methods, number of birth and breastfeeding, and incidence of cancer in children, but systematic reviews addressing this issue [...]

Auhtors: Law AMK, Valdes-Mora F, Gallego-Ortega D PMID: 32121014 PMCID: PMC7140518 DOI: 10.3390/cells9030561 Abstract The emergence of immunotherapy has been an astounding breakthrough in cancer treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have shown remarkable therapeutic outcomes. However, response rates from immunotherapy have been reported to be varied, with some having pronounced [...]

Auhtors: Alexandrov LB, Kim J, Haradhvala NJ, Huang MN, Tian Ng AW, Wu Y, et al. PMID: 32025018 PMCID: PMC7054213 DOI: 10.1038/s41586-020-1943-3 Abstract Somatic mutations in cancer genomes are caused by multiple mutational processes, each of which generates a characteristic mutational signature1. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium2 of [...]

Auhtors: Amaravadi RK, Kimmelman AC, Debnath J PMID: 31434711 PMCID: PMC7306856 DOI: 10.1158/2159-8290.CD-19-0292 Abstract Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and metabolic adaptation, has been implicated as a process that regulates cancer. Although autophagy induction may limit the development of tumors, evidence in mouse models demonstrates that autophagy inhibition can limit [...]

Authors: Amaravadi RK, Kimmelman AC, Debnath J PMID: 31434711 PMCID: PMC7306856 DOI: 10.1158/2159-8290.CD-19-0292 Abstract Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and metabolic adaptation, has been implicated as a process that regulates cancer. Although autophagy induction may limit the development of tumors, evidence in mouse models demonstrates that autophagy inhibition can limit [...]