Auhtors: Meynet O, Ricci JE PMID: 24916302 DOI: 10.1016/j.molmed.2014.05.001 Abstract Caloric restriction (CR) is currently the most robust environmental intervention known to increase healthy life and prolong lifespan in several models, from yeast to mice. Although the protective effect of CR on the incidence of cancer is well established, its impact on tumor cell responses [...]

Auhtors: Mulrooney TJ, Marsh J, Urits I, Seyfried TN, Mukherjee P PMID: 21479220 PMCID: PMC3068150 DOI: 10.1371/journal.pone.0018085 Abstract Background: Many of the current standard therapies employed for the management of primary malignant brain cancers are largely viewed as palliative, ultimately because these conventional strategies have been shown, in many instances, to decrease patient quality of [...]

Auhtors: Hursting SD, Smith SM, Lashinger LM, Harvey AE, Perkins SN PMID: 19969554 DOI: 10.1093/carcin/bgp280 Abstract Calorie restriction (CR) is arguably the most potent, broadly acting dietary regimen for suppressing the carcinogenesis process, and many of the key studies in this field have been published in Carcinogenesis. Translation of the knowledge gained from CR research [...]

Auhtors: Bonorden MJ, Rogozina OP, Kluczny CM, Grossmann ME, Grambsch PL, Grande JP, Perkins S PMID: 19235043 DOI: 10.1080/01635580802419798 Abstract Prostate cancer is the most frequently diagnosed cancer in men. Whereas chronic calorie restriction (CCR) delays prostate tumorigenesis in some rodent models, the impact of intermittent caloric restriction (ICR) has not been determined. Here, transgenic [...]

Auhtors: Zhou W, Mukherjee P, Kiebish MA, Markis WT, Mantis JG, Seyfried TN PMID: 17313687 PMCID: PMC1819381 DOI: 10.1186/1743-7075-4-5 Abstract Background: Malignant brain cancer persists as a major disease of morbidity and mortality in adults and is the second leading cause of cancer death in children. Many current therapies for malignant brain tumors fail to [...]

Auhtors: Kari FW, Dunn SE, French JE, Barrett JC PMID: 10885804 Abstract This paper focuses on the role of insulin-like growth factor-1 (IGF-1) and its associated regulatory apparatus as a key endocrine, autocrine, and paracrine signalling system involved in mediating the anti-carcinogenic activity of dietary restriction. Literature is reviewed showing that the inhibitory action of [...]