Auhtors: Zhao Z, Zeng J, Guo Q, Pu K, Yang Y, Chen N, et al. PMID: 34869024 PMCID: PMC8634032 DOI: 10.3389/fonc.2021.775418 Abstract Background: Cancer stem cells (CSCs) are able to survive after cancer therapies, resulting in tumor progression and recurrence, as is seen in colorectal cancer. Therapies targeting CSCs are regarded as novel and promising [...]

Auhtors: Azadi R, Mousavi SE, Kazemi NM, Yousefi-Manesh H, Rezayat SM, Jaafari MR PMID: 34600570 PMCID: PMC8487542 DOI: 10.1186/s40360-021-00525-7 Abstract Background: Berberine (BBR) is a plant alkaloid that possesses anti-inflammatory and anti-oxidant effects with low oral bioavailability. In this study, micelle formulation of BBR was investigated to improve therapeutic efficacy and examined its effect on [...]

Auhtors: El-Benhawy SA, El-Sheredy HG, Ghanem HB, El-Soud AAA doi: https://doi.org/10.2217/bmt-2020-0007 Abstract Aim: Our objective was to investigate the effect of ionizing radiation (IR) and berberine on the expression of stem cell markers OCT4 and SOX2. Materials & methods: The study involved the following groups: Group I: MCF-7 spheroids as untreated control; Group II: MCF-7 [...]

Auhtors: Jin F, Xie T, Huang X, Zhao X PMID: 31070539 PMCID: PMC6319470 DOI: 10.1080/13880209.2018.1548627 Abstract Context: Berberine is used in traditional Chinese medicine for thousands of years with recent reports of its anticancer activity. Objective: To test antiangiogenic effects of berberine on human glioblastoma and clarify involvement of the VEGFR2/ERK pathway. Materials and methods: [...]

Auhtors: Zou K, Zhao L, Young A, Zhand H-Y, Li B, Zhu W-L, et al. PMID: 27917872 PMCID: PMC5309756 DOI: 10.1038/aps.2016.125 Abstract It has been widely recognized that inflammation, particularly chronic inflammation, can increase the risk of cancer and that the simultaneous treatment of inflammation and cancer may produce excellent therapeutic effects. Berberine, an alkaloid [...]

Auhtors: Li Z, Geng YN, Jiang JD, Kong WJ PMID: 24669227 PMCID: PMC3942282 DOI: 10.1155/2014/289264 Abstract Oxidative stress and inflammation are proved to be critical for the pathogenesis of diabetes mellitus. Berberine (BBR) is a natural compound isolated from plants such as Coptis chinensis and Hydrastis canadensis and with multiple pharmacological activities. Recent studies showed [...]