Jorge R Miranda-Massari, Alondra P Toro, Doris Loh, Jose R Rodriguez, Raul Morales Borges, Victor Marcial-Vega, Jose Olalde, Miguel J Berdiel, Neil H Riordan, Juan Manuel Martinez, Armando Gil, Michael J Gonzalez PMID: 34947872 PMCID: PMC8708699 DOI: 10.3390/life11121341 AbstractCurrently available anti-viral drugs may be useful in reducing the viral load but are not providing the [...]

Authors: Al Sulaiman K, Al Juhani O, Badreldin HA, Salah KB, Alharbi A, Arabi YM doi: https://doi.org/10.21203/rs.3.rs-227158/v1 Abstract Background: Due to its supposed clinical efficacy, relative safety, and low cost, ascorbic acid represents an appealing option for clinicians to utilize in the context of a global health pandemic of COVID-19 patients. Objectives: The aim of [...]

Authors: Iglesias J, Vassallo AV, Patel V, Sullivan JB, Cavanaugh J, Elbaga Y PMID: 32194058 DOI: 10.1016/j.chest.2020.02.049 Abstract Background: Sepsis is a major public health burden resulting in 25% to 30% in-hospital mortality and accounting for over 20 billion dollars of US hospital costs. Research question: Does hydrocortisone, ascorbic acid, thiamine (HAT) therapy improve clinical [...]

Authors: Wang Y, Lin H, Lin BW, Lin JD PMID: 31111241 PMCID: PMC6527630 DOI: 10.1186/s13613-019-0532-9 Abstract Background: Low levels of ascorbic acid (AA) have been detected in critically ill patients in which AA supplementation leads to promising outcomes. However, the ability of AA to reduce mortality in critically ill patients remains controversial. In this study, [...]

Auhtors: Marik PE PMID: 30441816 PMCID: PMC6265973 DOI: 10.3390/nu10111762 Abstract Sepsis is a devastating disease that carries an enormous toll in terms of human suffering and lives lost. Over 100 novel pharmacologic agents that targeted specific molecules or pathways have failed to improve the outcome of sepsis. Preliminary data suggests that the combination of Hydrocortisone, [...]

Authors: Marik PE PMID: 30441816 doi: 10.3390/nu10111762 Abstract Sepsis is a devastating disease that carries an enormous toll in terms of human suffering and lives lost. Over 100 novel pharmacologic agents that targeted specific molecules or pathways have failed to improve the outcome of sepsis. Preliminary data suggests that the combination of Hydrocortisone, Ascorbic Acid [...]

Authors: Barabutis N, Khangoora V, Marik PE, Catravas JD PMID: 28739448 PMCID: PMC5812759 DOI: 10.1016/j.chest.2017.07.014 Abstract Background: Sepsis refers to the dysregulated host immune response elicited by microbial infections resulting in life-threatening organ dysfunction. Sepsis represents a medical challenge, since it is associated with a rate of death as high as 60%. Septic shock is [...]

Authors: Fletcher RH doi:10.1001/jamainternmed.2013.2305 Abstract Vitamin deficiency diseases, such as pellagra, rickets, beriberi, night blindness, and scurvy, used to account for an enormous burden of suffering worldwide. One by one, the underlying dietary deficiencies were defined, and, in the early part of the 20th century, the chemical structures of the missing nutrients were identified. While [...]

Oxidative stress acutely increases the permeability of the vascular endothelium to large molecules that would not otherwise cross the barrier. Ascorbic acid is an antioxidant that tightens the endothelial permeability barrier, so we tested whether it might also prevent the increase in endothelial permeability due to cellular oxidative stress.

Authors: May JM, Qu ZC PMID: 21328627 PMCID: PMC3725122 DOI: 10.1002/biof.134 Abstract Oxidative stress acutely increases the permeability of the vascular endothelium to large molecules that would not otherwise cross the barrier. Ascorbic acid is an antioxidant that tightens the endothelial permeability barrier, so we tested whether it might also prevent the increase in endothelial [...]