Authors: DiNicolantonio JJ, Barroso-Aranda J, McCarty MF PMID: 33875563 PMCID: PMC8057070 DOI: 10.1136/openhrt-2021-001655 Abstract Ivermectin, a drug commonly used to treat a range of parasitic infections, has been shown to halve the mortality elicited by a fatal dose of lipopolysaccharide in mice, in an oral dose (4 mg/kg) that can be extrapolated to 2–4 times the [...]

The SARS-CoV-2 virus spreading across the world has led to surges of COVID-19 illness, hospitalizations, and death. The complex and multifaceted pathophysiology of life-threatening COVID-19 illness including viral mediated organ damage, cytokine storm, and thrombosis warrants early interventions to address all components of the devastating illness. In countries where therapeutic nihilism is prevalent, patients endure escalating symptoms and without early treatment can succumb to delayed in-hospital care and death.

Authors: DiNicolantonio JJ, Barroso-Arranda J, McCarty M PMID: 32895293 PMCID: PMC7476419 DOI: 10.1136/openhrt-2020-001350 Abstract Ivermectin, on the WHO’s List of Essential Medications, has been in clinical use since 1981 as an orally and topically active agent for treating a range of parasitic infections in humans, including river blindness and lymphatic filariasis. It is also widely [...]

Authors: Kjellberg A, De Maio A, Lindholm P PMID: 33254531 PMCID: PMC7456590 DOI: 10.1016/j.mehy.2020.110224 Abstract Introduction: SARS-CoV-2 affects part of the innate immune response and activates an inflammatory cascade stimulating the release of cytokines and chemokines, particularly within the lung. Indeed, the inflammatory response during COVID-19 is likely the cause for the development of acute [...]

Approximately 9 months of the severe acute respiratory syndrome coronavius-2 (SARS-CoV-2 [COVID-19]) spreading across the globe has led to widespread COVID-19 acute hospitalizations and death. The rapidity and highly communicable nature of the SARS-CoV-2 outbreak has hampered the design and execution of definitive randomized, controlled trials of therapy outside of the clinic or hospital.

Auhtors: Hamblin MR PMID: 28748217 PMCID: PMC5523874 DOI: 10.3934/biophy.2017.3.337 Abstract Photobiomodulation (PBM) also known as low-level level laser therapy is the use of red and near-infrared light to stimulate healing, relieve pain, and reduce inflammation. The primary chromophores have been identified as cytochrome c oxidase in mitochondria, and calcium ion channels (possibly mediated by light [...]

Authors: Menezes RR, Godin AM, Rodrigues FF, Coura GM, Melo IS, Brito AM PMID: 28958614 DOI: 10.1016/j.pharep.2017.04.011 Abstract Background: The effects induced by thiamine and riboflavin, isolated or in association with corticosteroids, in models of chronic inflammation are not known. Thus, we evaluated the effect induced by these B vitamins, isolated or in association with [...]

Auhtors: Zou K, Zhao L, Young A, Zhand H-Y, Li B, Zhu W-L, et al. PMID: 27917872 PMCID: PMC5309756 DOI: 10.1038/aps.2016.125 Abstract It has been widely recognized that inflammation, particularly chronic inflammation, can increase the risk of cancer and that the simultaneous treatment of inflammation and cancer may produce excellent therapeutic effects. Berberine, an alkaloid [...]

Auhtors: Williamson T, Bai RY, Staedtke V, Huso D, Riggins GJ PMID: 27612418 PMCID: PMC5356574 DOI: 10.18632/oncotarget.11851 Abstract Inheritance of a gene mutation leads to the initiation of 5 to 10% of most cancers, including colon cancer cases. We developed a chemoprevention strategy using a novel combination of the non-steroidal anti-inflammatory (NSAID) sulindac plus the [...]

Auhtors: Li Z, Geng YN, Jiang JD, Kong WJ PMID: 24669227 PMCID: PMC3942282 DOI: 10.1155/2014/289264 Abstract Oxidative stress and inflammation are proved to be critical for the pathogenesis of diabetes mellitus. Berberine (BBR) is a natural compound isolated from plants such as Coptis chinensis and Hydrastis canadensis and with multiple pharmacological activities. Recent studies showed [...]