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Authors: Jayk Bernal A, da silva G, Musungaie DB, Kovalchuk A, Brown ML, Assaid C PMID: 34914868 PMCID: PMC8693688 DOI: 10.1056/NEJMoa2116044 Abstract Background: New treatments are needed to reduce the risk of progression of coronavirus disease 2019 (Covid-19). Molnupiravir is an oral, small-molecule antiviral prodrug that is active against severe acute respiratory syndrome coronavirus 2 [...]
Categories: I-CARE Early Covid
Tags: COVID-19, molnupiravir
Authors: Loucera C, Pena-Chilet M, Esteban-Medina M, Villegas R, Lopez-Miranda J PMID: 34862422 PMCID: PMC8642445 DOI: 10.1038/s41598-021-02701-5 Abstract COVID-19 is a major worldwide health problem because of acute respiratory distress syndrome, and mortality. Several lines of evidence have suggested a relationship between the vitamin D endocrine system and severity of COVID-19. We present a survival [...]
Categories: I-CARE Early Covid, MATH+
Tags: Calcifediol, COVID-19
Authors: Calusic M, Marcec R, Luksa L, Jurkovic I, Kovac N, Likic R PMID: 34719789 PMCID: PMC8653355 DOI: 10.1111/bcp.15126 Abstract Aims: Fluvoxamine, a selective serotonin reuptake inhibitor (SSRI) and sigma-1 receptor agonist, has so far shown promise in the prevention of COVID-19 progression as an early treatment option in three trials. The aim of this [...]
Categories: I-CARE Early Covid, MATH+
Tags: COVID-19, Fluvoxamine
Authors: Kennedy RF PMID: Abstract Over 1,000,000 copies sold despite censorship, boycotts from bookstores and libraries, and hit pieces against the author. Pharma-funded mainstream media has convinced millions of Americans that Dr. Anthony Fauci is a hero. Hands down, he is anything but. As director of the National Institute of Allergy and Infectious Diseases [...]
Categories: I-CARE Early Covid, MATH+
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Authors: Thomas R, Aldous J, Forsyth R, Chater A, Williams M. DOI: 10.29011/2577-1515.100182 Abstract Background: Gut microfloral dysbiosis is known to affect the majority individuals suffering with a Covid-19 infection. This study evaluated whether a specific lactobacillus and inulin blend, which aimed to improve gut health, could reduce the severity of early and chronic Covid-19 [...]
Categories: I-CARE Early Covid, I-PREVENT, I-RECOVER Post-Vaccine
Tags: COVID-19
Authors: Hoertel N PMID: 34779851 DOI: 10.1001/jamanetworkopen.2021.36510 Abstract In a large, multicenter, retrospective cohort study of 83 584 patients with laboratory-confirmed COVID-19 who had an emergency department or urgent care visit or were admitted for observation or hospitalized across 87 health care centers in the US, Oskotsky et al observed an association between selective serotonin reuptake [...]
Categories: I-CARE Early Covid
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Authors: Oskotsky T, Maric I, Tang A, Oskotsky B, Wong RJ, Sirota M PMID: 34779847 PMCID: PMC8593759 DOI: 10.1001/jamanetworkopen.2021.33090 Abstract Importance: Antidepressant use may be associated with reduced levels of several proinflammatory cytokines suggested to be involved with the development of severe COVID-19. An association between the use of selective serotonin reuptake inhibitors (SSRIs)-specifically fluoxetine [...]
Categories: I-CARE Early Covid, MATH+
Tags: Antidepressants, COVID-19
Authors: Reis G, Moreira-Silva EA, Silva DC, Thabane L, Guyatt GH, Mills EJ PMID: 34717820 PMCID: PMC8550952 DOI: 10.1016/S2214-109X(21)00448-4 Abstract Background: Recent evidence indicates a potential therapeutic role of fluvoxamine for COVID-19. In the TOGETHER trial for acutely symptomatic patients with COVID-19, we aimed to assess the efficacy of fluvoxamine versus placebo in preventing hospitalisation [...]
Categories: I-CARE Early Covid, MATH+
Tags: COVID-19, Fluvoxamine
Authors:Ramiall V, Zucker J, Tatonetti N. PMID: PMC7574268 DOI: 10.1101/2020.10.15.20213546 Abstract Background Respiratory distress requiring intubation is the most serious complication associated with coronavirus disease 2019 (COVID-19). Methods In this retrospective study, we used survival analysis to determine whether or not mortality following intubation was associated with hormone exposure in patients treated at New York [...]
Categories: I-CARE Early Covid, I-PREVENT
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Authors: Tran HT, Gigl M, Le NP, Dawid C, Lamy E PMID: 34681279 PMCID: PMC8538008 DOI: 10.3390/ph14101055 Abstract To date, there have been rapidly spreading new SARS-CoV-2 "variants of concern". They all contain multiple mutations in the ACE2 receptor recognition site of the spike protein, compared to the original Wuhan sequence, which is of great [...]
Categories: I-CARE Early Covid, I-RECOVER Post-Vaccine
Tags: ACE2 protein, COVID-19, dandelion, SARS-CoV-2