There are around 50 million cases of sepsis per year globally, and 1 in 5 deaths is associated with sepsis. Sepsis is a time-sensitive disease, and treatment should begin before a diagnosis is confirmed. These 8 clinical tips will help you manage and treat your hospitalized sepsis patients.

  1. Do not wait for the diagnosis to begin treatment with antibiotics.
  2. To diagnose sepsis, a clinician should check these labs:
    • Blood cultures
    • PCT (precalcitonin)
    • CBC with differential
    • Ferritin
    • Electrolyte panel with attention to monitoring
    • Magnesium
  3. It is important to note that too much fluid will increase mortality of the septic patient.
  4. For the patient that needs support of the vascular system, a norepinephrine infusion is recommended. The FLCCC MHAT Treatment Protocol should be used as the guide for treatment. The FLCCC MHAT Protocol includes melatonin, hydrocortisone, ascorbic acid (vitamin C), and thiamine.
  5. Melatonin 6-10 mg every night.
  6. Hydrocortisone 50 mg every 6 hours for 4 days and until the patient is off vasopressors. (Note: If treatment is less than 10 days, tapering the dose is not needed).
  7. Vitamin C 1.5 gms IV every 6 hrs for 12-16 IV doses. See our Sepsis Protocol for more detailed information at link below.
  8. Thiamine 200 mg IV every 12 hours.

For more information on the Sepsis Care Protocol:

For more information about the nutraceuticals in the MHAT Protocol: