Ivermectin: 0.4 to 0.6 mg/kg – one dose daily for at least 5 days or until symptoms resolve.
If symptoms persist longer than 5 days, consult a healthcare provider. See Table 1 for help with calculating correct dose. Due to a possible interaction between quercetin and ivermectin, these drugs should be staggered throughout the day (see Table 2). For COVID treatment, ivermectin is best taken with a meal or just following a meal, for greater absorption.

Hydroxychloroquine (HCQ): 200 mg twice a day for 5 to 10 days.
Best taken with zinc. HCQ may be taken in place of, or together with, ivermectin. While ivermectin should be avoided in pregnancy, the FDA considers HCQ safe in pregnancy. Given the pathway used by the Omicron variant to gain cell entry, HCQ may be the preferred drug for this variant.

Zinc: 75-100 mg daily.
Take with HCQ. Zinc supplements come in various forms (e.g., zinc sulfate, zinc citrate and zinc gluconate).

Mouthwash: 3 times a day.
Gargle three times a day (do not swallow) with an antiseptic-antimicrobial mouthwash containing chlorhexidine, cetylpyridinium chloride (e.g., Scope™, Act™, Crest™) or povidone-iodine.

Nasal spray with 1% povidone-iodine: 2-3 times a day.
Do not use for more than 5 days in pregnancy. If 1% product is not available, dilute the more widely available 10% solution (see box) and apply 4-5 drops to each nostril every 4 hours.

Aspirin: 325 mg daily (unless contraindicated).

Melatonin: 5-10 mg before bedtime (causes drowsiness).
Slow- or extended-release formulations preferred.

Curcumin (turmeric): 500 mg twice a day.
Curcumin has low solubility in water and is poorly absorbed by the body; consequently, it is traditionally taken with full fat milk and black pepper, which enhance its absorption.

Kefir and/or Bifidobacterium Probiotics.
NOTE: Depending on the brand, these products can be very high in sugar, which promotes inflammation. Look for brands without added sugar or fruit jellies and choose products with more than one strain of lactobacillus and bifidobacteria. Try to choose probiotics that are also gluten free, casein free, and soy free.

Vitamin C: 500-1000 mg twice a day.

Quercetin (or a mixed flavonoid supplement): 250 mg twice a day.
Due to a possible interaction between quercetin and ivermectin, these drugs should not be taken simultaneously (i.e., should be staggered at different times of day – see Table 2). As supplemental quercetin has poor solubility and low oral absorption, lecithin-based and nanoparticle formulations are preferred.

Home pulse oximeter
Monitoring of oxygen saturation is recommended in symptomatic patients, due to asymptomatic hypoxia. Take multiple readings over the course of the day and regard any downward trend as ominous. Baseline or ambulatory desaturation under 94% should prompt consultation with primary or telehealth provider, or evaluation in an emergency room. (See box for further guidance.)

• Only accept values associated with a strong pulse signal
• Observe readings for 30–60 seconds to identify the most common value
• Warm up extremities prior to taking a measurement
• Use the middle or ring finger
• Remove nail polish from the finger on which measurements are made

Nigella sativa (black cumin): If using seeds, take 80 mg/kg once a day (or 400 to 500 mg of encapsulated oil twice a day).

Vitamin D3: 10,000 IU daily (two 5,000 IU capsules) for two weeks.

B complex vitamins.

Nitazoxanide (NTZ): 600 mg twice a day for 5 days.

Fluvoxamine: 25-50 mg twice a day.
Can substitute fluoxetine (Prozac; 20-40mg daily) if fluvoxamine not available.
NOTE: Some individuals who are prescribed fluvoxamine experience acute anxiety, which needs to be carefully monitored for and treated by the prescribing clinician to prevent rare escalation to suicidal or violent behavior.

N-acetyl cysteine (NAC): 600-1200 mg orally twice a day.

Omega-3 fatty acids: 4 g daily.
Vascepa (Ethyl eicosapentaenoic acid); Lovaza (EPA/DHA); or alternative DHA/EPA. Vascepa and Lovaza tablets must be
swallowed and cannot be crushed, dissolved, or chewed.