Auhtors: Giraldo NA, Becht E, Remark R, Damotte D, Sautès-Fridman C, Fridman WH
PMID: 24487185 DOI: 10.1016/j.coi.2014.01.001
Abstract
A tumour grows in a complex microenvironment composed of stromal cells, lymphoid and myeloid cells, vascular and lymphatic vessels, and the resultant cytokine and chemokine milieu. In most primary tumours, a strong Th1/cytotoxic T cells infiltration correlates with a longer survival. This beneficial effect can be hampered by the presence of M2 polarized macrophages and high VEGF production. Recent studies revealed that the pattern of the tumour microenvironment remains a major prognostic factor even in the metastatic lesions, while been reproducible between the primary and metastatic tumour. Nevertheless the prognostic impact of the Th1/cytotoxic T cell infiltrate could be different according to the origin of the primary tumour. This model highlights a novel tumour cell-dependent immune contexture that predicts patient’s clinical outcome and has implications in the use of immunotherapies.
Keywords: immune contexture, tumor, tumor microenvironment
Source: https://pubmed.ncbi.nlm.nih.gov/24487185/
Archive: https://archive.is/bOb3B
