Authors: Tezgin D, Giardina C, Perdrizet GA, Hightower LE

PMID: 32253741 PMCID: PMC7332662 doi: 10.1007/s12192-020-01100-5


We present new data on the effects of HBOT on human kidney (HK-2) cell metabolism using a SeaHorse XF Analyzer to evaluate separately the state of mitochondrial and glycolytic energy metabolism. The data are discussed in the context of the concept of cellular caloristasis networks. The information on the changes in cellular energy metabolism stimulated by HBOT presented here provides new insights into the cellular energy state and mitochondrial environment in which sHSPs function. These data will be useful in forming testable hypotheses about the functions of translocated sHSPs in human mitochondria responding to stressors.

Keywords: HBOT, Hyperbaric oxygen therapy, Small HSPs, Mitochondria, Proteostasis, Caloristasis, Diabetic kidney disease, Oxidative stress, Cytoprotection