Medical Evidence

Ascorbic Acid

Numerous studies of the profound physiologic and clinical impacts of intravenous ascorbic acid (AA) in critical illness states have been published over the past two decades. The publications below range from multiple studies in septic shock demonstrating large outcome improvements, to CITRIS-ALI, the NIH funded multi-center randomized controlled trial in ARDS which found that high dose intravenous AA led to a statistically significant reduction in mortality. Timeliness of administration, i.e. the need for early infusion at the onset of critical illness, is a variable that has been poorly accounted for in many trials of intravenous AA and is well-illustrated in multiple studies below.

June 19, 2020 | USA/Italy/UK
Quercetin & Vitamin C: A synergistic therapy for prevention and treatment of COVID-19
“Quercetin and Vitamin C: An experimental, synergistic therapy for the prevention and treatment of SARS-CoV-2 related disease (COVID-19)”
https://doi.org/10.3389/fimmu.2020.01451

April, 2020 | USA
Impact of intravenous ascorbic acid in critical illness, database of all published trials
“Clinical trials of IV Ascorbic Acid, Thiamine RX, or HAT therapy in ICU patients with septic shock or ARDS” (spreadsheet)
https://docs.google.com/spreadsheets/d/e/2PACX-1vTc9ySK-KTeaylouVkYEto9an8kZehJ5dG6LwBAFgKj12_wtk4cd…

March 30, 2020 | USA
Importance of the timeliness of IV ascorbic acid initiation and relation to survival in shock patients
“Relationship between delays in iHAT administration and ICU mortality in shock patients” (graph)
/wp-content/uploads/2020/06/TIME-TO-HAT-INITIATION-AND-MORTALITY-ANALYSIS-IN-SEPTIC-SHOCK-N139.png

March 26, 2020 | China
High dose intravenous ascorbic acid used successfully in Covid-19
“Can early and high intravenous dose of vitamin C prevent and treat coronavirus disease 2019 (COVID-19)?” (Article on ScienceDirect)
https://doi.org/10.1016/j.medidd.2020.100028

March 17, 2020 | USA
Faster resolution of shock with early HAT treatment in sepsis
“The ORANGES trial – Outcomes of metabolic resuscitation using ascorbic acid, thiamine, and glucocorticoids in the early treatment of sepsis”
https://doi.org/10.1016/j.chest.2020.02.049

January 9, 2020 | USA
HAT therapy reduces mortality in septic children
“Hydrocortisone–ascorbic acid–thiamine use associated with lower mortality in pediatric septic shock”
https://doi.org/10.1164/rccm.201908-1543le

December 23, 2019 | USA
The anti-viral properties of Vitamin C
Editorial on Taylor & Francis Online by Ruben M. L. Colunga Biancatelli, Max Berrill and Paul E. Marik (FLCCC)
https://doi.org/10.1080/14787210.2020.1706483

October 1, 2019 | USA
Intravenous ascorbic acid reduces mortality in ARDS
The CITRIS-ALI Randomized Clinical Trial – “Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure”
https://doi.org/10.1001/jama.2019.11825

July 21, 2017 | USA
Corticosteroid and ascorbic acid act synergistically in protecting the pulmonary endothelial barrier
“Hydrocortisone and Ascorbic Acid Synergistically Prevent and Repair Lipopolysaccharide-Induced Pulmonary Endothelial Barrier Dysfunction” (Study)
https://doi.org/10.1016/j.chest.2017.07.014

June, 2017 | USA
HAT therapy for treatment of severe sepsis & septic shock
A retrospective before-after study
https://doi.org/10.1016/j.chest.2016.11.036