Medical Evidence

Ascorbic Acid

Numerous studies of the profound physiologic and clinical impacts of intravenous ascorbic acid (AA) in critical illness states have been published over the past two decades. The publications below range from multiple studies in septic shock demonstrating large outcome improvements to CITRIS-ALI, the NIH funded multi-center randomized controlled trial in ARDS which found that high dose intravenous AA led to a statistically significant reduction in mortality. Timeliness of administration, i.e. the need for early infusion at the onset of critical illness is a variable that has been poorly accounted for in many trials of intravenous AA and is well-illustrated in multiple studies below.