In the United States, 20-40% of whites and hispanics have MTHFR gene mutation (C677T). This mutation leads to reduced function of MTHFR enzyme to 65% of normal. The second most common mutation leads to reduced function of MTHFR enzyme, to 30% of normal.

The result of these performance issues is reduced methyl groups’ availability for methylation functions. The likelihood of clotting in the cardiovascular system increases because of the endothelial impaired function, clotting factor abnormalities, and increased levels of reactive oxygen species (ROS).