Authors: Kuyandik A, Ozcan E, Serin S, Sungurtekin H

DOI: 10.4274/tybd.galenos.2021.91885


ABSTRACT Reports of neurological problems are increasing for the clinical presentation of COVID19. The clinical presentation reported in this study seemed to be a combination of nonspecific complications of the systemic disease, inflammation of the cerebrovascular system, and the effects of a direct viral infection. Creutzfeldt–Jakob disease, a spongiform encephalopathy caused by prions, is characterized by a severe neurological destruction, which has an extremely high mortality. In this publication, we presented a patient who was admitted to the Pamukkale University Anesthesiology Intensive Care Units with the neurological findings that developed after the COVID-19 vaccine (CoronaVac, Sinovac Life Sciences, Beijing, China). The patient died due to the progressive neurological disorders. In cases where rapidly progressive neurological disorders are observed, Creutzfeldt–Jakob disease should be considered and the role of immunity-related conditions in the progression of the disease should be investigated.

Keywords: Covid-19, Vaccine, Creutzfeldt–Jakob disease, Prion protein