Long Story Short

During the wakeful hours, the production of norepinephrine increases. This increase helps with alertness, but also causes vasoconstriction. The outcome is a reduction in the interstitial fluid levels and reduction in the clearance of waste products. During sleep, NE levels reduce, reversing the above mentioned mechanisms, leading to more interstitial fluid movement and more glymphatic clearance of the waste products and better brain health.

In ‘The Sleeping Brain’ article, the authors suggest that sleep disturbance causes reduced removal of the waste products from the brain, leading to the accumulation of beta amyloids - which in turn is observed in Alzheimer's disease. Studies present an association between APOE4 and sleep disturbance. Additionally APOE4 is linked to sleep disturbance before the onset of Alzheimer's symptoms. Additionally, it is thought that APOE directly leads to beta amyloid metabolism disturbance. And, finally, it is thought that stress-related proteolytic cleavage of APOE4 leads to accumulation of tau proteins. Let's review the evidence.

The N3 phase of sleep is characterized by delta waves, also called slow wave sleep (SWS). This is the most restorative phase, marked by an increase in the glymphatic convection in the brain leading to clearance of the waste products.

Intermittent fasting causes production of beta hydroxybutarate, which in turn helps improve the glymphatic flow of fluids in the brain. This in turn leads to a better clearance of waste products from the brain, helping to improve the cognitive state, memory, and potentially stall the progress of dementia.

Berberine has many important mechanisms. In the current series of talks we examine the management of Type 2 diabetes mellitus and how Berberine helps increase insulin secretion.

Metabolic Syndrome is the starting topic in the second in a series of lectures on the incredible Chinese herbal medicine, berberine. This episode of 'Long Story Short' comes to us from the February 8, 2023 FLCCC Weekly Webinar with Dr. Mobeen Syed (Dr. Been) and Dr. Paul Marik.

The herbal Chinese medicine has an amazing effect on insulin release, insulin resistance and improvement in liver-cell health.

Magnesium is an essential mineral/nutrient in more than 600 enzymatic actions in our body. Tied closely with the activation of vitamin D, Magnesium is involved in smooth muscle relaxation, neuroprotection, innate arm modulation, gut microbiome modulation and much more.

Melatonin and Near Infrared Light (NIR) -- Being in the morning and evening sunlight and being in the green places should be an important part of life. Let's see why.

Today’s discussion looks at the latest study on long COVID symptom clusters and their proportions. The findings are fascinating.

The second of the three-part lecture on Nattokinase -- a thrombolytic, spike protein degradative, and anti-aging enzyme produced by Bacillus subtilis.

Nattokinase is a thrombolytic, spike-protein degradative and anti-aging enzyme produced by Bacillus subtilis. Nattokinase is made by fermenting soybeans with Bacillus subtilis. Dr. Been reviews its actions in the first of a three-part lecture series.

Back by popular demand -- Dr. Marik joins Dr. Been and reviews the latest research on intermittent fasting (IF) for women.

Photobiomodulation and methylene blue are neuroprotective. These interventions not only reduce cellular apoptosis, but also improve the tissue healing by improving the blood flow to the tissues. Let's review how photobiomodulation works to help mitochondria heal and function correctly.

In this talk Dr. Been reviews the FLCCC's recommendation for the oral methylene blue dosage found in the I-RECOVER Protocol.

Methylene Blue (MB) Dosage and Administration Approaches Numerous reviews studies that have shown the neuroprotective effect of methylene blue (MB). It seems that MB can be used for brain fog, confusion, memory issues and mitochondrial dysfunction in neurons.

Dr. Been reviews studies showing that neurons are metabolically protected when low-dose Methylene Blue is administered systemically.

Types of Protein Recycling and Inflammatory Diseases is for healthcare providers to manage patients with chronic inflammatory diseases more successfully.

This week's topic, Antinuclear Antibodies: A Primer for Providers, is dedicated to help healthcare providers identify and treat Long COVID.

Antinuclear Antibodies as Predictors of Long COVID drills down a Canadian study about the persistence of the ANA and inflammatory mediators that predict Long COVID symptoms.

In this discussion Dr. Been reviews the important pathologic mechanisms behind the diseases caused by the spike protein.

In one more episode of Long (COVID) Story Short, Dr. Been explains how the spike protein can cause dysregulation of the ACE2 bearning cells.

How To Impart Superpowers To Your Cells - Dr. Been goes over the fundamentals of heat shock proteins, and is hopeful the "discussion will encourage us to become partners with our cells in staying healthy."

Near Infrared Light Therapy Reduces Inflammation is the 26th Long Story Short, and features Dr. Been's trademark hand-drawn illustrations and reviews NIR's anti-inflammatory properties and potential benefit to everyone currently battling Long COVID.

When the RNA Won't Go Away is Dr. Been's 25th episode of Long Story Short and features a ground-breaking case that demonstrates, for the first time, the evidence for the SARS-COV-2 persistence, or Long COVID. Let's review.

How to Maximize Autophagy and When Does Autophagy Begin? Dr. Ana Maria Cuervo, MD, Ph.D notes that macroautophagy starts within 30 minutes to an hour of starvation. When do we starve? In the intermittent fasting of 8-16. The macroautophagy starts within 8 hours if there are no snacks. The chaperon mediated autophagy occurs during the 16 hours. If you keep the 16 hours window including the sleep then the neurons are able to perform autophagy as well.

Unusual Symptoms and Risk Factors takes a look at a large-scale matched pair study from the UK where researchers describe the top risk factors for Long COVID.

Cardiovascular Effects COVID-19 Vaccine in Adolescents examines a study from Thailand on school children receiving BNT162b2 mRNA COVID-19 vaccines.

Coffee Achievers take note, this week Dr. Been reviews a study from Singapore that demonstrates how caffeine helps reduce lipid fats by inducing autophagy — the concept that the host heals itself. Intermittent Fasting-induced autophagy is an essential element of FLCCC’s I-RECOVER protocols. Recently Dr. Mark said, “There is only one way to get rid of spike protein, and that’s by stimulating autophagy. That is the only way.”

Spike protein is something we have heard a lot about over the past couple of years, but how does the spike protein actually cause cell damage?

Dr. Been reviews the research of the four main predictors of Long COVID.

COVID and Changes in Brain Structure is the inaugural episode of the Long Story Short with Dr. Been. This week Dr. Been reviews the latest research and developments related to Long COVID and changes in brain size and structure.

Dr. Been examines two studies focused on Reinfection and Risk of Long COVID and Severe Outcomes – one from the U.S. VA Hospital system and one from Qtar. 

This week Dr. Been examines the Zoe app study that demonstrated in some cases the risk of Long COVID in the Omicron era is 76% less than Long COVID in the Delta era. The findings of the study were published as a letter in the Lancet.

Brain Fog and Neurogenesis is Lecture 14 of Long Story Short, Dr. Been examines Brain Fog and Long COVID. "As the pandemic of neurological and neuropsychiatric issues continues to expand because of Long COVID and vaccine injuries, it is important for us all to understand what lifestyle and diet changes may help combat the neurological deterioration and restore the neurogenesis process."

In this in-vitro study researchers from the University of Munich show that dandelion leaf extract has a potent inhibitory effect on the SARS-COV-2 spike binding to ACE2.

T-Regulatory Cells and Chronic Inflammation completes the chronic inflammation series, reviews a promising area of immunology and reveals "the big topic -- T Regulatory (TReg) cells" and their function.

Chronic Inflammation: Immune Regulation Mechanisms continues the chronic inflammation series, with a deeper dive in order to understand the regulatory mechanisms of the immune system.

Chronic Inflammation: Pathogen Elimination and Important Inflammatory Cytokines covers the mechanisms at the core of chronic inflammation. Dr. Been also discusses how the inflammatory process is executed to contain microbes, repair tissue damage and to remove microbes, damaged  tissue cells, worn out cells and irritants.

Chronic Inflammation: A High-Level Overview points out that 50% of worldwide deaths occur due to the diseases with underlying chronic inflammation. Sixty percent of Americans have a chronic inflammatory condition and more than 20% have more than one chronic inflammatory disease.

For lecture eight in the series, Dr. Been focuses on Long COVID, Chronic Fatigue Syndrome.

How Polyethylene Glycol (PEG) in Vaccines May Cause Allergic Reactions explains that PEG is an important part of the lipid nanoparticles based vaccines.

Dr. Been discusses a study from the UK and US that helps define and outline the characteristics and prolonged symptoms of Long COVID.

The Prevalence of Long COVID in the UK and Common Symptoms Dr. Been reviews a 2020 study and wraps up with a study of Long COVID characteristics in France.

This week Dr. Been examines the Epstein Barr Virus (EBV) and Long COVID in four videos.

Post-Vaccine Pediatric Patients and Cardiac Issues analyzes the study Persistent MRI Findings in Children After Pfizer Vaccine, Seattle Children's Hospital. A follow-up on children that had myocarditis from the second dose of the Pfizer-BionTech vaccine.

Diabetes and Long COVID is the second video from Dr. Been, and looks at a study discussing the incidence of diabetes and Long COVID.

Welcome to the inaugural episode of the Long Story Short with Dr. Been podcast. This week Dr. Been reviews the latest research and developments related to Long COVID and changes in brain size and structure. Please watch and share