Role of the T cell vitamin D receptor in severe COVID-19
Published On: July 8, 2020|
Kolls JK, Garry RF.
PMID: 34931078 DOI: 10.1038/s41590-021-01098-7
New research provides evidence of an impaired vitamin D gene signature in CD4+ T cells in patients with severe COVID-19. Mechanistically, it is shown that vitamin D alters the epigenetic landscape of CD4+ T cells, as well as inducing key transcription factors such as STAT3, BACH2 and JUN that reduce levels of IFN-γ and increase IL-10. These changes generate pro-resolving TH1 cells that may be beneficial in resolving or preventing severe COVID-19.