Authors: Pont G, Pastorino L, Manfredini M, Ozben T, Oliva G, Kaleci S

PMID: 34061414 PMCID: PMC8209953 DOI: 10.1002/jcla.23798


Background: Homocysteine assessment has been proposed as a potential predictive biomarker for the severity of COVID-19 infection. The purpose of this review was to analyze the correlation between the prevalence of MTHFR C677 T gene polymorphism and COVID-19 incidence and mortality worldwide.

Methods: Data regarding MTHFR C677 T gene mutation were obtained from the interrogation of the Genome Aggregation Database (genomAD), which is publicly available from the web”” COVID-19 cases, including prevalence and mortality, were obtained from”” 27 August 2020.

Results: There is a clear trend toward the worldwide prevalence of MTHFR 677 T and COVID-19 incidence and mortality. The prevalence of MTHFR 677 T allele in the Latino population, and the incidence and mortality for COVID-19 was higher for this ethnic group than that reported for most other populations globally. Statistical analysis showed a relatively strong correlation between C677 T and death from coronavirus.

Conclusions: Genetic polymorphism of MTHFR C677 T may modulate the incidence and severity of COVID-19 pandemic infection.

Keywords: C677 T mutation prevalence; COVID-19 vulnerability; Homocysteine; MTHFR gene.