Authors: Shodell M, Siegal FP

PMID: 11544466 DOI: 10.1067/mai.2001.117928


Glucocorticoids are strongly immunosuppressive and are associated with reactivation of some intracellular infections. The plasmacytoid dendritic cell is a rare blood mononuclear cell detected through its production of IFN-alpha in response to herpes simplex virus and by surface immunophenotyping. We here report that steroid administration results in a decrease of IFN-alpha generation of approximately 25-fold, accompanied by reduction in circulating plasmacytoid dendritic cell numbers. Both parameters return to normal within days after steroid cessation.

Keywords: corticosteriods, plasmacytoid dendritic cells, Glucocorticoids, immunosuppressive, IFN-alpha

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More on: Corticosteroids