Thiamine is another cornerstone in the concept of “metabolic resuscitation”, an approach based on the concept that once severe or critical illness develops, multiple deficiencies in key vitamins and hormones are created via “consumption” induced via the body’s attempts to fight off the insult or invader. Immediate and aggressive repletion of such substances are critical to strengthening the immune system’s ability to maintain balance and prevent the onset-of-multi-organ failure. The studies below detail the critical functions of thiamine, the deleterious consequences and high incidence of thiamine deficiency and also includes several key studies demonstrating improvements in survival with aggressive intravenous thiamine repletion.
Journal of Thoracic Disease
“Effect of Thiamine administration on lactate clearance and mortality in patients with septic shock” (Critical Care Magazine – Nov 2018 – Vol. 46 – Issue 11)
Randomized, double-blind, placebo-controlled trial of Thiamine as a metabolic resuscitator in septic shock – A pilot study (Critical Care Magazine – Feb 2016 – Vol. 44 – Issue 2)