Medical Evidence

Additional Medicines

The studies below detail both the biologic plausibility supporting each adjunctive medicine, and the emerging clinical evidence base, demonstrating their impacts on survival in multiple critical illness states, including the emerging evidence for their use in COVID-19.

June 24, 2020 | China
Statin use is associated with a lower risk of all-cause mortality
“In-hospital use of statins is associated with a reduced risk of mortality among individuals with COVID-19” (Retrospective Study)
https://doi.org/10.1016/j.cmet.2020.06.015

June 10, 2020 | Singapore
Vitamin-Magnesium combo may reduce severity of COVID-19 in seniors
A cohort study to evaluate the effect of combination Vitamin D, Magnesium and Vitamin B12 (DMB) on progression to severe outcome in older COVID-19 patients
https://doi.org/10.1101/2020.06.01.20112334

May 22, 2020 | USA
Famotidine associated with improved clinical outcomes in hospitalized COVID-19 patients
“Famotidine Use is Associated with Improved Clinical Outcomes in Hospitalized COVID-19 Patients: A Propensity Score Matched Retrospective Cohort Study”
https://pubmed.ncbi.nlm.nih.gov/32446698/?from_term=famotidine+COVID-19&from_pos=2

May 15, 2020 | USA/Spain
Therapeutic algorithm for use of Melatonin in patients with COVID-19
Review of the evidence for a role of Melatonin as a COVID-19 treatment
https://doi.org/10.3389/fmed.2020.00226

April 28, 2020 | USA
Vitamin D insufficiency is prevalent in severe COVID-19
Retrospective review
https://www.medrxiv.org/content/10.1101/2020.04.24.20075838v1

April, 2020 | USA
The role of Vitamin D in suppressing cytokine storm and mortality in COVID-19
A retrospective review of the relationship between Vitamin D and Covid-19 infection and mortality
https://www.medrxiv.org/content/10.1101/2020.04.08.20058578v4

April 2, 2020 | USA/Hungary
Evidence that Vitamin D could reduce risk of COVID-19 infections and deaths
Review on the role of Vitamin D in reducing the risk of respiratory tract infections
https://pubmed.ncbi.nlm.nih.gov/32252338/

December 15, 2019 | USA/Italy/UK
Melatonin for the treatment of sepsis: the scientific rationale
Review on the evidence for the role of Melatonin in sepsis, its pharmacokinetic profile and the virtual absence of side effects
http://dx.doi.org/10.21037/jtd.2019.12.85

May 4, 2017 | Germany
Persistent low serum Zinc associated with recurrent sepsis in critically ill
A pilot study
https://pubmed.ncbi.nlm.nih.gov/28472045/

March 24, 2016 | USA/Thailand
Hypomagnesemia and mortality in patients admitted to intensive care unit
A systematic review and meta-analysis
https://doi.org/10.1093/qjmed/hcw048

November 4, 2010 | Netherlands
Zinc inhibits Coronavirus activity in vitro and blocks viral replication
“Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture”
https://pubmed.ncbi.nlm.nih.gov/21079686/

June, 2006 | Saudi Arabia
Aggressive Magnesium supplementation associated with improved survival
“Magnesium supplementation and the potential association with mortality rates among critically ill non-cardiac patients”
https://pubmed.ncbi.nlm.nih.gov/16758043/

April, 2003 | Belgium
Development of ionized hypomagnesemia is associated with higher mortality rates
Prospective observational study
https://doi.org/10.1097/01.ccm.0000060867.17556.a0