Is ivermectin safe and are there any contraindications for use?

Since its discovery in 1975, ivermectin was awarded the Nobel Prize in Medicine, included on the WHO’s “List of Essential Medicines”, and been administered more than 4 billion times.

Ivermectin is a remarkably safe drug with minimal adverse reactions (almost all minor). However, potential drug-drug interactions should be reviewed before prescribing ivermectin. The most important drug-drug interactions occur with cyclosporin, tacrolimus, antiretroviral drugs, and certain antifungal drugs.